$refractory insomnia meaning$

$refractory insomnia meaning$

Reid KJ, Jaksa AA, Eisengart JB, Baron KG, Lu B, Kane P, et al. The associations of insomnia symptoms and chronotype with daytime sleepiness, mood symptoms and suicide risk in adolescents. Sleep timing and circadian phase in delayed sleep phase syndrome. Delayed sleep phase syndrome in adolescents: prevalence and correlates in a large population based study. Sivertsen B, Pallesen S, Stormark KM, Boe T, Lundervold AJ, Hysing M. Sleep and academic performance in later adolescence: results from a large population-based study. Hysing M, Harvey AG, Linton SJ, Askeland KG, Sivertsen B.

$refractory insomnia meaning$

Melanopsin-dependent phototransduction is impaired in delayed sleep-wake phase disorder and sighted non-24-hour sleep-wake rhythm disorder. Diagnosis, cause, and treatment approaches for delayed sleep-wake phase disorder. Magee M, Marbas EM, Wright KP Jr, Rajaratnam SM, Broussard JL. Roenneberg T, Kuehnle T, Pramstaller PP, Ricken J, Havel M, Guth A, et al.

$refractory insomnia meaning$

Circadian rhythm sleep-wake disorders: gaps and opportunities. Darien, IL: American Academy of Sleep Medicine 2014.ĭuffy JF, Abbott SM, Burgess HJ, Crowley SJ, Emens JS, Epstein LJ, et al. International classification of sleep disorders. III, “Gates” and “Forbidden Zones” for Sleep. Nonphotic entrainment in humans? J Biol Rhythms. The etiology of delayed sleep phase disorder. Micic G, Lovato N, Gradisar M, Ferguson SA, Burgess HJ, Lack LC. High sensitivity and interindividual variability in the response of the human circadian system to evening light. Phillips AJK, Vidafar P, Burns AC, McGlashan EM, Anderson C, Rajaratnam SMW, et al. Phototransduction by retinal ganglion cells that set the circadian clock. Stability, precision, and near-24-hour period of the human circadian pacemaker. 2017 18(3):164–79.Ĭzeisler CA, Duffy JF, Shanahan TL, Brown EN, Mitchell JF, Rimmer DW, et al. Transcriptional architecture of the mammalian circadian clock. Our hypothesis is that the therapy with pregabalin may be indicated for resistant insomnia associated with subsyndromal RLS, even when the latter does not satisfy fully all the criteria for diagnosis.Takahashi JS. Her intractable insomnia was markedly responsive to pregabalin without side effects. Her resistant insomnia was treated with benzodiazepine sleeping drugs (triazolam 0.25 mg, lorazepam 2.5 mg, fluorazepam 30 mg) with only partial insomnia remission, antidepressants (trazodone 150 mg RP, mirtazapine 15-30 mg, agomelatine 50 mg) and antipsychotics (levomepromazine 25 mg, zuclopentixol 25 mg) without results. Nevertheless, a mild depression, an intermittent awakening (fragmentation of the sleep-wake rhythm) and subsyndromal RLS persisted. After treatment with paroxetine (20 mg) and zolpidem (10 mg), anxiety and mood deflection were attenuated. Although this last symptom was very distressing, it did not satisfy the criteria for RLS (Restless Legs Syndrome). We diagnosed her case as depression with high levels of anxiety, weakness, with diminished ability to think or concentrate and with a sensory-motor disorder. We report a case with refractory insomnia.

$refractory insomnia meaning$

Refractory insomnia meaning